##  [Home](/home) 

 .llnl-bg-7d6274e8 { background-image: linear-gradient(rgba(0, 0, 0, 0), rgba(0, 0, 0, 0)), url(https://bioresilience.llnl.gov/sites/bioresilience/files/styles/orig/public/2024-04/cpb-hero-feature-image-V2-bg%402x.jpg?itok=oSe7804W); } 

 ![Center for Predictive Bioresilience](https://bioresilience.llnl.gov/sites/bioresilience/files/styles/scaled_877w/public/2024-03/cpb-web-logo.png?itok=CWdaYpjZ "Center for Predictive Bioresilience")



 





 

 

 

 

 

 

## Become a CPB partner

The Center for Predictive Bioresilience is making Lawrence Livermore National Laboratory’s high performance computing resources available to dedicated partners in DOE, academia, and industry for biological research. Learn how we work with our partners to extend and refine our unique approach to medical countermeasure design.



 





 

[  Learn About Partnering](https://bioresilience.llnl.gov/collaboration)



 





 

 

 

 

## Overview

The Center for Predictive Bioresilience (CPB) is an interdisciplinary group focused on using high performance computing and experimental platforms to accelerate research timelines. CPB is integrating computational and laboratory capabilities to accelerate the design of medical countermeasures, such as vaccines and therapeutics, to be on the order of weeks instead of years. We are also developing improved predictive models to create early warning systems for the purpose of avoiding the next pandemic. CPB is LLNL’s hub for collaboration between computational and experimental biology.

## Our Research

The Center for Predictive Bioresilience’s unique approach to research and development brings the power of high-performance computing models to develop countermeasures for existing and emerging biological threats. Our current research areas include:



 





 

 

 

 

 

[ ](https://bioresilience.llnl.gov/research-areas/#early-warning)

### Early Warning & Threat Assessment

 

 

[ ](https://bioresilience.llnl.gov/research-areas/#accelerated-countermeasures)

### Accelerated Countermeasure Design

 

 

[ ](https://bioresilience.llnl.gov/research-areas#safety-security)

### Safety & Security for AI-guided Biosystem Design

 

 

 

 





 

 

 

 

 

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  ![](/sites/bioresilience/files/styles/orig/public/2024-03/homepage-slider-preventing-the-next-pandemic.png?itok=-XXCMKci) 

 ### Preventing the next pandemic

Researchers are working to identify and respond to new biothreats more quickly and effectively. Learn more about how they’re using an innovative mix of advanced simulation and machine learning to develop drugs that can disarm existing biothreats and be optimized to address emergent ones.



 

   

  ![](/sites/bioresilience/files/styles/orig/public/2024-03/homepage-slider-making-better-decisions-through-data-image.jpg?itok=z9MQFzZz) 

 ### Making better decisions through data

The Center for Predictive Bioresilience is working to build out data ecosystems to promote cutting-edge collaborations. Backed by the Laboratory’s high-performance computing hardware, the CPB hopes to create an inclusive environment where data is accessible to external partners as well as researchers inside LLNL.

[  Learn more about our data](https://bioresilience.llnl.gov/resources#data-ecosystem)



 

   

 

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## CPB resources

The Center for Predictive Bioresilience (CPB) brings together biotechnology, high-performance computing, and artificial intelligence to quickly identify emerging biothreats and create effective countermeasures. This integrated capability draws from decades of experimentally validated computational models.



 





 

 

 

 

[ ](https://bioresilience.llnl.gov/resources/#hardware)

### Hardware

 

 

[ ](https://bioresilience.llnl.gov/resources/#software)

### Software

 

 

[ ](https://bioresilience.llnl.gov/resources/#data-ecosystem)

### Data Ecosystem

 

 

[ ](https://bioresilience.llnl.gov/resources/#platforms)

### Experimental Platforms

 

 

 

 





 

 

 

 

 ![National Nuclear Security Administration](https://bioresilience.llnl.gov/sites/bioresilience/files/styles/scaled_150w/public/2024-03/logo-nnsa.png?itok=TVPrhG2z "National Nuclear Security Administration")

 ![Department of Defense](https://bioresilience.llnl.gov/sites/bioresilience/files/styles/thumbnail/public/2024-02/dod-logo.png?itok=M_dvwFZW "Department of Defense")

 ![Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense](https://bioresilience.llnl.gov/sites/bioresilience/files/styles/thumbnail/public/2024-02/jpeo-cbd-logo.png?itok=uLsSUJKA "Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense")



 







 

## CPB sponsors

Whether natural or man-made, biological threats are a serious and growing national security concern. Our sponsors are committed to combatting biothreats with world-class computing resources, experimental capabilities, and exceptional staff.

- [National Nuclear Security Administration](https://www.energy.gov/nnsa/national-nuclear-security-administration)
- [Office of the Assistant Secretary of Defense for Nuclear, Chemical, and Biological Defense Programs](https://www.acq.osd.mil/ncbdp/cbd/index.html)
- [Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense](https://www.jpeocbrnd.osd.mil/ "Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense")



 





 

 

 

 

 

## Work with the Center for Predictive Bioresilience

Collaboration is a key element of CPB’s success. Learn more about how we work with industry, academic, and national laboratories to extend and refine our unique approach to medical countermeasure design.



 





 

[ Collaborate with us](https://bioresilience.llnl.gov/collaboration)